Scientists have developed a 3D bioprinting platform that assembles functional मानव neural tissues. The progenitor cells in the printed tissues grow to form neural circuits and make functional connections with other neurons thus mimicking natural brain tissues. This is a significant progress in neural tissue engineering and in 3D bioprinting technology. Such bioprinted neural tissues can be used in modelling मानव diseases (such as Alzheimer’s, Parkinson’s etc.) caused due to impairment of neural networks. Any investigation of disease of brain requires understanding how the मानव neural networks operate.
थ्रीडी बायोप्रिन्टिङ यो एक additive प्रक्रिया हो जहाँ उपयुक्त प्राकृतिक वा सिंथेटिक बायोमटेरियल (बायोइन्क) लाई जीवित कोशिकाहरूसँग मिलाइन्छ र प्रिन्ट गरिएको, तह-दर-तह, प्राकृतिक ऊतक-जस्तै-तीन-आयामी संरचनाहरूमा। कोशिकाहरू बायोइन्कमा बढ्छन् र प्राकृतिक तन्तु वा अंगको नक्कल गर्न संरचनाहरू विकास हुन्छन्। यस प्रविधिले मा अनुप्रयोगहरू फेला पारेको छ पुनर्जन्म medicine for bioprinting of cells, tissues and organs and in research as model to study मानव जीउ कृत्रिम परिवेशीय, खास गरी मानव स्नायु प्रणाली।
को अध्ययन मानव nervous system faces limitations due to unavailability of primary samples. Animal models are helpful but suffer from species-specific differences hence the imperative of कृत्रिम परिवेशीय models of the मानव nervous system to investigate how the मानव neural networks operate towards finding treatments for diseases attributed to impairment of neural networks.
मानव neural tissues have been 3D printed in the past using stem cells however these lacked neural network formation. The printed tissue had not shown to have formed connections between cells for several reasons. These shortcomings have been overcome now.
In a recent study, researchers chose fibrin hydrogel (consisting of fibrinogen and thrombin) as the basic bioink and planned to print a layered structure in which progenitor cells could grow and form synapses within and across layers, but they changed the way layers are stacked during printing. Instead of traditional way of stacking layers vertically, they chose to print layers next to another horizontally. Apparently, this made the difference. Their 3D bioprinting platform was found to assemble functional मानव neural tissue. An improvement over other existing platforms, the मानव neural tissue printed by this platform formed neural networks and functional connections with other neurons and glial cells within and between layers. This is the first such case and is a significant step forward in neural tissue engineering. Laboratory synthesis of nerve tissue that mimics brain in function sounds exciting. This progress will certainly help researchers in modelling मानव diseases of brain caused due to impaired neural network to better understand the mechanism for finding a possible treatment.
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सन्दर्भ:
- क्याडेना एम।, एट अल 2020. न्यूरल टिस्युजको थ्रीडी बायोप्रिन्टिङ। उन्नत हेल्थकेयर सामग्री खण्ड 3, अंक 10 15। DOI: https://doi.org/10.1002/adhm.202001600
- यान वाई, एट अल 2024. 3D bioprinting of मानव neural tissues with functional connectivity. Cell Stem Cell Technology| Volume 31, Issue 2, P260-274.E7, February 01, 2024. DOI: https://doi.org/10.1016/j.stem.2023.12.009
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